Disruption of the Oxysterol 7α-Hydroxylase Gene in Mice
نویسندگان
چکیده
منابع مشابه
Original Article Differences in Expression of Cholesterol 7α-Hydroxylase between PHHC and Wistar Rats (cholesterol 7α-hydroxylase gene / gene expression / PHHC rats / hypercholesterolemia)
PHHC rats represent a suitable experimental model of polygenic hypercholesterolemia. It has been found that its metabolic defect is not related to alimentary cholesterol absorption and LDL clearance. We have tested possible changes in cholesterol clearance from the liver to bile acids by analysis of the expression of the cholesterol 7α-hydroxylase (cyp7A1) gene in PHHC (N = 20) and Wistar (cont...
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15 صفحه اولDeficiency of cholesterol 7α‐hydroxylase in bile acid synthesis exacerbates alcohol‐induced liver injury in mice
Alcoholic fatty liver disease (AFLD) is a major risk factor for cirrhosis-associated liver diseases. Studies demonstrate that alcohol increases serum bile acids in humans and rodents. AFLD has been linked to cholestasis, although the physiologic relevance of increased bile acids in AFLD and the underlying mechanism of increasing the bile acid pool by alcohol feeding are still unclear. In this s...
متن کاملGlucose stimulates cholesterol 7α-hydroxylase gene (CYP7A1) transcription in human hepatocytes
متن کامل
Diurnal variation in cholesterol 7α-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene
AIM To determine whether the promoter polymorphism -203A>C of cholesterol-7α-hydroxylase encoding gene (CYP7A1) affects diurnal variation in CYP7A1 enzyme activity. METHODS The study included 16 healthy male volunteers - 8 homozygous for -203A and 8 homozygous for the -203C allele of CYP7A1. Three 15-hour examinations (from 7am to 10pm) were carried out for each of the participants: after one...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.m001811200